Start by seasoning the chicken breasts with dried oregano, garlic powder, onion granules, paprika, salt, and black pepper. Heat the air fryer and cook the chicken until golden and cooked through. Use a meat thermometer to ensure the chicken reaches 165 degrees F, taking care not to overcook and dry it out.
Meanwhile, fill a large pot with water and bring it to a boil. Add penne pasta and cook until al dente, stirring occasionally to prevent sticking. Taste the pasta before draining to ensure it is cooked to your liking.
In the same skillet used for the chicken, heat the olive oil over medium heat. Add the finely diced onion and sauté until the onion is translucent and aromatic, about 3-4 minutes. Avoid browning the onion to prevent bitterness.
Stir in the chopped garlic and cook until fragrant, about 1 minute. Then mix in the tomato paste and red chili flakes, allowing the mixture to cook for a couple of minutes to deepen the flavors.
Carefully add vodka to the skillet, letting it simmer for 3-4 minutes to cook off the alcohol. The aroma of the sauce will become richer as it cooks.
Lower the heat and stir in the half and half and grated Parmesan. Allow the sauce to thicken and become creamy, coating the back of a spoon. Adjust seasoning if needed.
Add the drained penne pasta to the sauce in the skillet. Toss everything together to ensure the pasta is well-coated, adjusting the consistency if necessary with reserved pasta water.
Serve the pasta garnished with fresh basil leaves and additional salt and black pepper to taste.